In search of new treatment modalities of COVID-19, cell-based therapy with mesenchymal stem cells (MSCs) and/or their secretome, such as soluble bioactive factors and extracellular vesicles, is considered supportive therapy for critically ill patients. Multipotent MSCs are able to differentiate into different types of cells of mesenchymal origin, including alveolar epithelial cells, lung epithelial cells, and vascular endothelial cells, which are severely damaged in the course of COVID-19 disease.
Co-culture of MSCs isolated from human skin (green) and bone marrow (red), magnification x200
Live cell imaging of MSCs isolated from human skin, stained with green at passage P6, and co-cultured with MSCs isolated from human bone marrow, stained with red at passage 2. Check out #Co-culture of MSCs at https://db.binwit.pl/en/stem-cells/Coculture/415
138 years ago – on 2 September 1883 – the inventor of the world’s first effective vaccine against spotted fever, Rudolf Stefan Jan Weigl, was born in Przerów. The street where the Ludwik Hirszfeld Institute of Immunology and Experimental Therapy of the Polish Academy of Sciences in Wrocław is located is named after Professor Weigl.
The first photo of our T4 phage taken with a JEOL F-200 transmission electron microscope (TEM). A microscopic preparation of T4 phage prepared by the team at IITD PAN.
We would like to invite you to the scientific symposium entitled “Single cell and spatial transcriptomics symposium”, which will be held on July 1, 2021 at 10:00 a.m. in the Slopek Hall of the Ludwik Hirszfeld Institute of Immunology and Experimental Therapy, Polish Academy of Sciences, Wrocław, 12 Weigl Street.
The Hirszfeld Institute Phage group published the article “Phages in the fight against COVID-19?” in the “Future Microbiology”. Authors discusses new perspectives for the innovative use of phage therapy not only in the treatment of bacterial infections, but also in the treatment of viral infections, possibly including COVID-19.
